MCAT-TEST Online Practice Questions and Answers

Our sense of smell is arguably the most powerful of our five senses, but it also the most elusive. It plays a vital yet mysterious role in our lives. Olfaction is rooted in the same part of the brain that regulates such essential functions as body metabolism, reaction to stress, and appetite. But smell relates to more than physiological function: its sensations are intimately tied to memory, emotion, and sexual desire. Smell seems to lie somewhere beyond the realm of conscious thought, where, intertwined with emotion and experience, it shapes both our conscious and unconscious lives.

The peculiar intimacy of this sense may be related to certain anatomical features. Smell reaches the brain more directly than do sensations of touch, sight, or sound. When we inhale a particular odor, air containing volatile odiferous molecules is warmed and humidified as it flows over specialized bones in the nose called turbinates. As odor molecules land on the olfactory nerves, these nerves fire a message to the brain. Thus olfactory neurons render a direct path between the stimulus provided by the outside environment and the brain, allowing us to rapidly perceive odors ranging from alluring fragrances to noisome fumes.

Certain scents, such as jasmine, are almost universally appealing, while others, like hydrogen sulfide (which emits a stench reminiscent of rotten eggs), are usually considered repellent, but most odors evoke different reactions from person to person, sometimes triggering strong emotional states or resurrecting seemingly forgotten memories. Scientists surmise that the reason why we have highly personal associations with smells is related to the proximity of the olfactory and emotional centers of our brain. Although the precise connection between emotion and olfaction remains a mystery, it is clear that emotion, memory, and smell are all rooted in a part of the brain called the limbic lobe.

Even though we are not always conscious of the presence of odors, and are often unable to either articulate or remember their unique characteristics, our brains always register their existence. In fact, such a large amount of human brain tissue is devoted to smell that scientists surmise the role of this sense must be profound. Moreover, neurobiological research suggests that smell must have an important function because olfactory neurons can regenerate themselves, unlike most other nerve cells. The importance of this sense is further supported by the fact that animals experimentally denied the olfactory sense do not develop full and normal brain function.

The significance of olfaction is much clearer in animals than in human beings. Animal behavior is strongly influenced by pheromones, which are odors that induce psychological or behavioral changes and often provide a means of communicating within a species. These chemical messages, often a complex blend of compounds, are of vital importance to the insect world. Honeybees, for example, organize their societies through odor: the queen bee exudes an odor that both inhibits worker bees from laying eggs and draws drones to her when she is ready to mate. Mammals are also guided by their sense of smell. Through odors emitted by urine and scent glands, many animals maintain their territories, identify one another, signal alarm, and attract mates.

Although our olfactory acuity can't rival that of other animal species, human beings are also guided by smell. Before the advent of sophisticated laboratory techniques, physicians depended on their noses to help diagnose illness. A century ago, it was common medical knowledge that certain bacterial infections carry the musty odor of wine, that typhoid smells like baking bread, and that yellow fever smells like meat. While medical science has moved away from such subjective diagnostic methods, in everyday life we continue to rely on our sense of small, knowingly or not, to guide us.

The author describes the sense of smell as elusive because:

A. odiferous molecules are extremely volatile.

B. the functions of smell are emotional rather than physiological.

C. the function and effects of smell are not fully understood.

D. olfactory sensations are more fleeting than those of other senses.

Studies of photosynthesis began in the late eighteenth century. One scientist found that green plants produce a substance (later shown to be oxygen) that supports the flame of a candle in a closed container. Several years later it was discovered that a plant must be exposed to light in order to replenish this flame- sustaining "substance". Soon another discovery showed that the oxygen is formed at the expense of another gas, carbon dioxide.

In 1804, de Saussure conducted experiments revealing that equal volumes of carbon dioxide and oxygen are exchanged between a plant and the air surrounding it. De Saussure determined that the weight gained by a plant grown in a pot equals the sum of the weights of carbon derived from absorbed carbon dioxide and water absorbed through plant roots. Using this information, de Saussure was able to postulate that in photosynthesis carbon dioxide and water combine using energy in the form of light to produce carbohydrates, water, and free oxygen. Much later, in 1845, scientists' increased understanding of concepts of chemical energy led them to perceive that, through photosynthesis, light energy is transformed and stored as chemical energy.

In the twentieth century, studies comparing photosynthesis in green plants and in certain sulfur bacteria yielded important information about the photosynthetic process. Because water is both a reactant and a product in the central reaction, it had long been assumed that the oxygen released by photosynthesis comes from splitting the carbon dioxide molecule. In the 1930s, however, this popular view was decisively altered by the studies of C. B. Van Niel. Van Niel studied sulfur bacteria, which use hydrogen sulfide for photosynthesis in the same way that green plants use water, and produce sulfur instead of oxygen. Van Niel saw that the use of carbon dioxide to form carbohydrates was similar in the two types of organisms. He reasoned that the oxygen produced by green plants must derive from water -- rather than carbon dioxide, as previously assumed -- in the same way that the sulfur produced by the bacteria derives from hydrogen sulfide. Van Niel's finding was important because the earlier belief had been that oxygen was split off from carbon dioxide, and that carbon then combined with water to form carbohydrates. The new postulate was that, with green plants, hydrogen is removed from water and then combines with carbon dioxide to form the carbohydrates needed by the organism.

Later, Van Niel's assertions were strongly backed by scientists who used water marked with a radioactive isotope of oxygen in order to follow photosynthetic reactions. When the photosynthetically-produced free oxygen was analyzed, the isotope was found to be present.

According to the passage, C. B. Van Niel's experiments:

A. provided the first model of photosynthesis.

B. showed that the carbon dioxide molecule is split during photosynthesis.

C. proved that some organisms combine hydrogen sulfide with carbon dioxide in photosynthesis.

D. provided evidence that weakened the accepted model of photosynthesis.

Just as the ingestion of nutrients is mandatory for human life, so is the excretion of metabolic waste products. One of these nutrients, protein, is used for building muscle, nucleic acids, and countless compounds integral to homeostasis. However, the catabolism of the amino acids generated from protein digestion produces ammonia, which, if not further degraded, can become toxic. Similarly, if the same salts that provide energy and chemical balance to cells are in excess, fluid retention will occur, damaging the circulatory, cardiac, and pulmonary systems.

One of the most important homeostatic organs is the kidney, which closely regulates the excretion and reabsorption of many essential ions and molecules. One mechanism of renal function involves the secretion of antidiuretic hormone (ADH).

Diabetes insipidus (DI), is the condition that occurs when ADH is ineffective. As a result, the kidneys are unable to concentrate urine, leading to excessive water loss. There are two types of DI -- central and nephrogenic. Central DI occurs when there is a deficiency in the quantity or quality of ADH produced. Nephrogenic DI occurs when the kidney tubules are unresponsive to ADH. To differentiate between these two conditions, a patient's urine osmolarity is measured both prior to therapy and after a 24-hour restriction on fluid intake. Exogenous ADH is then administered and urine osmolarity is measured again. The table below gives the results of testing on four patients. Assume that a urine osmolarity of 285 mOsm/L of H2O is normal.

According to the passage, the catabolism of amino acids produces ammonia. Therefore, after a proteinrich meal, would you expect a build-up of ammonia in the lumen of the small intestine?

A. Yes, because the ammonia will not be able to diffuse into the intestinal epithelium.

B. Yes, because the rate at which digestive enzymes degrade ammonia is slower than the rate at which ammonia is produced.

C. No, because the ammonia will diffuse into the intestinal epithelium and will be excreted by the kidneys.

D. No, because the ammonia is produced inside individual cells, not within the lumen of the small intestine.

The mechanism for the acid-catalyzed esterification of a carboxylic acid, carried out with R'OH, is shown below. The tagged alcohol R'18OH is used to study the reaction mechanism. The resulting ester is separated from the reaction mixture; the water from the reaction mixture is then distilled off completely and collected as a separate fraction.

Esterification may also occur between parts of the same molecule. Which of the following compounds would most easily undergo internal esterification to form a cyclic ester?

A. Option A

B. Option B

C. option C

D. Option D

Before birth, the rodent brain is sexually undifferentiated. It is only in the first few days following birth, during a period referred to as the critical period, that the rodent brain differentiates along male or female lines. The hormone testosterone plays a critical role in this development. Specifically, sexual differentiation is determined by the presence of estradiol, an estrogen derivative of testosterone, in certain areas of the brain. Testosterone is converted to estradiol in critical brain cells that contain the enzyme aromatase. To study the effects of testosterone on the neonatal rodent brain, the following experiments were conducted: The above research, combined with additional studies, concluded that testosterone has two "organizational" effects on the male rodent brain: Defeminization Moderate levels of testosterone-derived estradiol during the critical period are sufficient for defeminization of the brain. Defeminization of the rodent brain results in loss of estrogen positive feedback on LH and FSH secretion and the ensuing loss of cyclicity, as well as loss of female sex behavior. Masculinization High levels of estradiol due to high levels of testosterone during the critical period results in masculinization of the brain. Masculinization leads to the induction of male sex behavior including antagonism towards other males and the mounting of females.

In Experiment 2, researchers most likely waited 2-3 months before implanting ovaries:

A. to allow the rat to recover from previous surgery.

B. to allow testosterone levels to rise to necessary concentrations.

C. to wait for the critical period to pass.

D. to promote the defeminization of the rat brain.

One of the most common methods that scientists use to determine the age of fossils is known as carbon dating. 14C is an unstable isotope of carbon that undergoes beta decay with a half-life of approximately 5,730 years. Beta decay occurs when a neutron in the nucleus decays to form a proton and an electron which is ejected from the nucleus. 14C is generated in the upper atmosphere when 14N, the most common isotope of nitrogen, is bombarded by neutrons. This mechanism yields a global production rate of 7.5 kg per year of 14C, which combines with oxygen in the atmosphere to produce carbon dioxide. Both the production and the decay of 14C occur simultaneously. This process continues for many half-lives of 14C, until the total amount of 14C approaches a constant. A fixed fraction of the carbon ingested by all living organisms will be 14C. Therefore, as long as an organism is alive, the ratio of 14C to 12C that it contains is constant. After the organism dies, no new 14C is ingested, and the amount of 14C contained in the organism will decrease by beta decay. The amount of 14C that must have been present in the organism when it died can be calculated from the amount of 12C present in a fossil. By comparing the amount of 14C in the fossil to the calculated amount of 14C that was present in the organism when it died, the age of the fossil can be determined. The method of carbon dating used to determine age depends upon the assumption that:

A. the half-life of 14C changes when it is ingested.

B. all ingested 14C is incorporated into the body.

C. the half-life of 14C depends on the type of molecule in which it resides.

D. the half-life of 14C does not depend upon conditions external to the 14C nucleus.

Historically, two different methods have been used to estimate the fluid pressure in capillary beds.

Method 1 A glass pipette is inserted into the capillary. The level of blood rising in the pipette is measured and used to calculate the pressure. Alternatively, an inert fluid of density can be placed in the pipette and its height h can be measured. The pressure in the capillary is given by gh, where g is the acceleration due to gravity.

Figure 1

Method 2 The pressure can be measured indirectly in the following way. A section of gut tissue is removed from a specimen and placed on a beam balance. Blood is circulated through the tissue by a pump. The arterial pressure is then decreased. This leads to a decrease in the capillary hydrostatic pressure in the gut capillaries. The constant osmotic pressure of plasma proteins in the capillary causes absorption of fluid from the gut section which will decrease its weight. To prevent a change in the weight of the gut section, the venous pressure is increased. This tends to increase the capillary pressure, reducing the flow of fluid from the gut tissue into the capillaries. The capillary pressure is thus held constant (and the balance kept level) as the arterial pressure is decreased and the venous pressure increased. The arterial and venous pressures meet at the capillary pressure being measured.

( = MRT, where is the osmotic pressure, M the molarity of the solutes, R the universal gas constant, and T the temperature in Kelvin.)

Figure 2

Assume that a mass (m) of 0.2 kg is placed 25 cm to the right of the fulcrum. A section of gut, initially weighing 0.1 kg is placed 50 cm to the left of the fulcrum. During the experiment, the mass m is seen to descend. In order to maintain the balance level the following action should be taken:

A. the mass m should be moved away from the fulcrum.

B. the arterial pressure should be decreased.

C. the venous pressure should be increased.

D. an inert fluid with higher density than that of blood should be used in the pipette.

How much average force should be applied to 2500 Kg car, having velocity of 30 m/s, in order to stop the in 15 seconds?

A. 1000 N

B. 6000 N

C. 5000 N

D. 8000 N

In the course of gathering data in an experiment, a researcher develops the following correlation matrix:

Table 1 Correlation Matrix

Which of the following pairs of variables are most strongly correlated?

A. A, C

B. A, D

C. B, D

D. C, D

In the United States, breast cancer is the second leading cause of death for women, and as a result, the American Cancer Society, has recommended annual mammography screening for women age 40 years and older. It is estimated that the risk of mortality can be reduced through this procedure by approximately 20-25% during a ten-year period for women age 40 years and older.

In general, cancer screening behaviors have increased in the United States. According to the National Health Interview Survey, in 1987, approximately 29% of women age 40 years and older reported having had a mammogram in the last 2 years. By 2000, this increased to 70%. However, there are racial disparities, as fewer African American and Hispanic women have mammograms compared to their Caucasian female counterparts. Some studies have looked into these differences. Cultural factors seem to play a role in minority women obtaining fewer mammograms. Asian women, for example, do not like to discuss sensitive topics with strangers.

Prevention promotions have been designed to increase awareness for the need of breast cancer screening, particularly for women in racial and ethnic minority groups. An innovative breast cancer education program, called the Educational Intervention Asian Grocery Store-Based Education Program, was designed to target Asian women. Located in 20 different Asian grocery stores in communities, the cancer screening exhibits were placed at the entrances of the stores. As Asian women came into the grocery store, health information was passed out to Asian women. Even though only a small amount of women who were considered non-adherents to breast cancer screening ended up scheduling a screening, the study demonstrated an innovative culturally competent approach to health promotion.

Source: Adapted from G.R. Sadler, P.R. Beerman, K. Lee et al. "Promoting Breast Cancer Screening Among Asian American Women: The Asian Grocery Store Based Cancer Education Program." Copyright 2012 Journal of Cancer Education.

After learning about the foot-in-the-door technique, what might a health promoter do so to promote Asian women to sign up for a mammogram appointment?

A. Give them a 15-minute lecture on the importance of early prevention.

B. Promote the cultural concept of "loss of face" by informing them that the sponsors of the Educational Intervention Asian Grocery Store-Based Education Program put in a lot of money into the program and will lose face if progress is not made.

C. Encourage them to take a free shopping bag that includes a box of tea bags and a brochure about mammograms.

D. Tell them that many other Asian women have signed up right on the spot.